array(2) { ["lab"]=> string(4) "1409" ["publication"]=> string(5) "12602" } One-pot synthesis of 3-fluoroflavones via 1-(2-hydroxyphenyl)-3-phenylpropane-1, 3-diones and selectfluor at room temperature - Liang Yong | LabXing

Liang Yong

简介 中藥質量控制資訊系統，生物資訊學

大学 Macau University of Science and Technology / Faculty of Information Technology
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One-pot synthesis of 3-fluoroflavones via 1-(2-hydroxyphenyl)-3-phenylpropane-1, 3-diones and selectfluor at room temperature

2018
期刊 Organic & biomolecular chemistry
A concise and efficient one-pot strategy to synthesize 3-fluoroflavones was developed. 1-(2-Hydroxyphenyl)-3-phenylpropane-1,3-diones were fluorinated using selectfluor with a small amount of CH3CN at room temperature, followed by cyclization and dehydration in the presence of a trace amount of conc. H2SO4 to provide 3-fluoroflavones. The desired 3-fluoroflavone analogues were obtained in moderate to excellent yields. This strategy tolerated a wide range of functional groups and did not need sophisticated instruments or tedious substrate preparation.

  • 卷 16
  • 期 14
  • 页码 2479-2488
  • Royal Society of Chemistry
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