肖百龙实验室

作者 Weijia Sun · Shaopeng Chi · Yuheng Li · Shukuan Ling · Yingjun Tan · Youjia Xu · Fan Jiang · Jianwei Li · Caizhi Liu · Guohui Zhong · Dengchao Cao · Xiaoyan Jin · Dingsheng Zhao · Xingcheng Gao · Zizhong Liu · Bailong Xiao · Yingxian L

A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

2018

期刊 Nature Communications

作者 Yanfeng Wang · Shaopeng Chi · Huifang Guo · Guang Li · Li Wang · Qiancheng Zhao · Yu Rao · Liansuo Zu · Wei He · Bailong Xiao

A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome

2018

期刊 Cell Reports

作者 Yifei Zhang · Hua Rong · Fang-Xiong Zhang · Kun Wu · Libing Mu · Junchen Meng · Bailong Xiao · Gerald W. Zamponi · Yan Shi

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

2018

期刊 Cell Discovery

作者 Si Wang · Boqiang Hu · Zhichao Ding · Yujiao Dang · Jun Wu · Di Li · Xiaoling Liu · Bailong Xiao · Weiqi Zhang · Ruotong Ren · Jinghui Lei · Huifang Hu · Chang Chen · Piu Chan · Dong Li · Jing Qu · Fuchou Tang · Guang-Hui Liu

Piezo channel mechanisms in health and disease

2018

期刊 The Journal of Physiology

作者 David J. Beech · Bailong Xiao

Structure and mechanogating mechanism of the Piezo1 channel

2018

期刊 Nature

作者 Qiancheng Zhao · Heng Zhou · Shaopeng Chi · Yanfeng Wang · Jianhua Wang · Jie Geng · Kun Wu · Wenhao Liu · Tingxin Zhang · Meng-Qiu Dong · Jiawei Wang · Xueming Li · Bailong Xiao

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

2018

期刊 Science

作者 Pan X · Li Z* · Zhou Q · Shen H · Wu K · Huang X · Chen J · Zhang J · Zhu X · Lei J · Xiong W · Gong H · Bailong Xiao · Yan N

The mechanosensitive Piezo1 channel: a three‐bladed propeller‐like structure and a lever‐like mechanogating mechanism

2018

期刊 The FEBS Journal

作者 Qiancheng Zhao · Heng Zhou · Xueming Li · Bailong Xiao

A protein interaction mechanism for suppressing the mechanosensitive Piezo channels

2017

期刊 Nature Communications

作者 Tingxin Zhang · Shaopeng Chi · Fan Jiang · Qiancheng Zhao · Bailong Xiao

In Touch With the Mechanosensitive Piezo Channels

2017

书籍 Current Topics in Membranes

作者 J. Geng · Q. Zhao · T. Zhang · B. Xiao

The mechanosensitive Piezo1 channel: structural features and molecular bases underlying its ion permeation and mechanotransduction

2017

期刊 The Journal of Physiology

作者 Yubo Wang · Bailong Xiao

Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels

2016

期刊 Neuron

作者 Qiancheng Zhao · Kun Wu · Jie Geng · Shaopeng Chi · Yanfeng Wang · Peng Zhi · Mingmin Zhang · Bailong Xiao

Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation

2016

期刊 Journal of Peptide Science

作者 Huan Lan · Kun Wu · Yong Zheng · Man Pan · Yi-Chao Huang · Shuai Gao · Qing-Yun Zheng · Ji-Shen Zheng · Yi-Ming Li · Bailong Xiao · Lei Liu

Architecture of the mammalian mechanosensitive Piezo1 channel

2015

期刊 Nature

作者 Jingpeng Ge · Wanqiu Li · Qiancheng Zhao · Ningning Li · Maofei Chen · Peng Zhi · Ruochong Li · Ning Gao · Bailong Xiao · Maojun Yang

Inflammatory Signals Enhance piezo2-Mediated Mechanosensitive Currents

2013

期刊 Biophysical Journal

作者 Adrienne Dubin · Manuela Schmidt · Jayanti Mathur · Matthew J. Petrus · Bailong Xiao · Bertrand Coste · Ardem Patapoutian

Piezo proteins are pore-forming subunits of mechanically activated channels

2012

期刊 Nature

作者 Bertrand Coste · Bailong Xiao · Jose S. Santos · Ruhma Syeda · Jörg Grandl · Kathryn S. Spencer · Sung Eun Kim · Manuela Schmidt · Jayanti Mathur · Adrienne E. Dubin · Mauricio Montal · Ardem Patapoutian

Scratching the surface: a role of pain-sensing TRPA1 in itch

2011

期刊 Nature Neuroscience

作者 Bailong Xiao · Ardem Patapoutian

Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression

2011

期刊 Nature Chemical Biology

作者 Bailong Xiao · Bertrand Coste · Jayanti Mathur · Ardem Patapoutian

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

2008

期刊 Journal of Neuroscience

作者 B. Xiao · A. E. Dubin · B. Bursulaya · V. Viswanath · T. J. Jegla · A. Patapoutian

Localization of PKA phosphorylation site, Ser2030, in the three-dimensional structure of cardiac ryanodine receptor

2008

期刊 Biochemical Journal

作者 Peter P. Jones · Xing Meng · Bailong Xiao · Shitian Cai · Jeff Bolstad · Terence Wagenknecht · Zheng Liu · S. R. Wayne Chen

An Ion Channel Essential for Sensing Chemical Damage

2007

期刊 Journal of Neuroscience

作者 L. J. Macpherson · B. Xiao · K. Y. Kwan · M. J. Petrus · A. E. Dubin · S. Hwang · B. Cravatt · D. P. Corey · A. Patapoutian

Functional Consequence of Protein Kinase A-dependent Phosphorylation of the Cardiac Ryanodine Receptor

2007

期刊 Journal of Biological Chemistry

作者 Bailong Xiao · Xixi Tian · Wenjun Xie · Peter P. Jones · Shitian Cai · Xianhua Wang · Dawei Jiang · Huihui Kong · Lin Zhang · Keyun Chen · Michael P. Walsh · Heping Cheng · S. R. Wayne Chen

Three-Dimensional Localization of Serine 2808, a Phosphorylation Site in Cardiac Ryanodine Receptor

2007

期刊 Journal of Biological Chemistry

作者 Xing Meng · Bailong Xiao · Shitian Cai · Xiaojun Huang · Fei Li · Jeff Bolstad · Ramon Trujillo · Judith Airey · S. R. Wayne Chen · Terence Wagenknecht · Zheng Liu

Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon β-adrenergic stimulation in normal and failing hearts

2006

期刊 Biochemical Journal

作者 Bailong Xiao · Guofeng Zhong · Masakazu Obayashi · Dongmei Yang · Keyun Chen · Michael P. Walsh · Yakhin Shimoni · Heping Cheng · Henk Ter Keurs · S. R. Wayne Chen

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A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel

Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the E-cadherin-β-catenin mechanotransduction complex

Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice

STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice

Structure and mechanogating of the mammalian tactile channel PIEZO2

The mechanosensitive Piezo1 channel is required for bone formation

A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

Piezo channel mechanisms in health and disease

Structure and mechanogating mechanism of the Piezo1 channel

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

The mechanosensitive Piezo1 channel: a three‐bladed propeller‐like structure and a lever‐like mechanogating mechanism

A protein interaction mechanism for suppressing the mechanosensitive Piezo channels

In Touch With the Mechanosensitive Piezo Channels

The mechanosensitive Piezo1 channel: structural features and molecular bases underlying its ion permeation and mechanotransduction

Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels

Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation

Architecture of the mammalian mechanosensitive Piezo1 channel

Inflammatory Signals Enhance piezo2-Mediated Mechanosensitive Currents

Piezo proteins are pore-forming subunits of mechanically activated channels

Scratching the surface: a role of pain-sensing TRPA1 in itch

Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

Localization of PKA phosphorylation site, Ser2030, in the three-dimensional structure of cardiac ryanodine receptor

An Ion Channel Essential for Sensing Chemical Damage

Functional Consequence of Protein Kinase A-dependent Phosphorylation of the Cardiac Ryanodine Receptor

Three-Dimensional Localization of Serine 2808, a Phosphorylation Site in Cardiac Ryanodine Receptor

Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon β-adrenergic stimulation in normal and failing hearts