Isogenic cells could have vastly different phenotypes. Such phenotypic heterogeneity is stochastic in its nature, but is also highly regulated. Phenotypic heterogeneity ensures poulation survival in the face of extreme environments, but is also deleterious as it lowere the population-average fitness by driving some individuals away from the phenotypic optimum. It has also been implicated in antibiotic resistance bacteria or chemo-resistance of cancer cells. We aimed to identify genetic regulators of phenotypic heterogeneity using high-throughput phenotyping data.
系统与进化基因组学实验室
研究随机现象如何影响生物的功能与进化
Genetic regulation of phenotypic heterogeneity
创建: Dec 31, 2020 | 10:47